Anxiety and stress are high on the list of reasons people turn to CBD for help. Many people are finding relief of their symptoms with a daily dose of CBD. But what can we learn from research studies ?

Watch this video for an interesting insight into how CBD works for anxiety

In 2011 a number of people participated in a study for the purpose of researching the effect of CBD Cannabidiol on social anxiety disorder. They were asked to speak in front of a large audience. Researchers compared anxiety levels in people after they took CBD, compared to those who got the placebo.
People who took CBD reported significantly less anxiety” compared to those who got the placebo,

How Does CBD Elicit Its Anti-Anxiety Effects

CBD is known to interact with or influence the CB1 and CB2 receptors of the body’s endocannabinoid system, which is responsible for regulating several body processes. While more research still needs to be done to fully understand the mechanisms of CBD’s anti-anxiety effects, evidence so far suggests that CBD reduce anxiety levels in three ways:

  • 5-HT1A agonist: CBD has shown to enhance the transmission of 5-HT1A receptors, which manage the release of serotonin. Low serotonin levels in the brain have been linked to depression and anxiety disorders, while more serotonin is thought to improve mood.
  • CB1 and CB2 receptor: CBD’s interaction with the CB1 and CB2 cannabinoid receptors helps to inhibit fatty acid amide hydrolase, an enzyme that degrades the endocannabinoid anandamide. Anandamide exhibits both anti-anxiety and antidepressant properties, and by helping prevent its degradation, CBD reduces the vulnerability to anxiety.
  • Hippocampal neurogenesis: CBD’s influence on CB2 receptors encourages the hippocampus of the brain to regenerate neurons. The hippocampus is a major part of the brain that is instrumental in cognition and memory formation, so the birth of new neurons could be beneficial for treating depression and anxiety. While evidence shows that anxiety and even suicidal behaviors can be partly attributed to severely impaired neuronal plasticity, studies have shown that CBD encourages neurogenesis and is neuroprotective.

A review of research into the therapeutic potential of Cannabidiol (CBD)  has shown there is a growing body of evidence to suggest that it could help in the treatment of anxiety-related and substance abuse disorders. However, more studies are needed to determine the psychological, pharmacological and brain mechanisms involved.

The British Journal of Pharmacology review, carried out by a team led by Dr Carl Stevenson, a behavioural neuroscientist in the School of Biosciences at the University of Nottingham, looked at the results of studies that have investigated cannabidiol’s effects on various fear and drug memory processes.

Dr Stevenson said: “Cannabis is best known for the ‘high’ caused by the chemical Tetrahydrocannabinol (THC) but it contains many other chemicals with potential medicinal properties, including cannabidiol. This chemical isn’t linked to the cannabis ‘high’ and it is safe for people to use so it might be helpful for alleviating certain symptoms of these disorders without having the unwanted side effects of cannabis.”

If you would like to discuss any of these findings with us please email [email protected]

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The content on these pages are in no way intended to offer any related health benefits to our products but merely to share opinions and any research findings.


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