CBD & Multiple Sclerosis
As more and more studies are conducted into medicinal and therapeutic applications of CBD, they produce incredibly compelling evidence of its numerous capabilities. The reason it has been found so effective with neurological disorders such as MS is its ability to help prevent neurodegeneration and alleviate, and possibly even reverse, various autoimmune issues.
One 2015 study conducted by various departments at the Research Institute of Neurochemistry in Madrid, Spain determined that CBD can help relieve several neurodegenerative disorders and trauma due to stroke and/or brain injury. A study by the Department of Pathology at the University of South Carolina published in the October 2009 issue of Future Medicinal Chemistry concluded that because of the way CBD interacts with CB2 receptors in the immune system, the molecule can help fight immunosuppression that often occurs in MS cases.
In addition, various studies have shown CBD to be incredibly effective in fighting inflammation. The Spanish study also found that CBD can decrease inflammatory responses in the nervous system, thereby helping to mitigate MS symptoms.
Results of a Phase 1 clinical trial in healthy volunteers show that PTL101, an oral cannabidiol compound, is a safe and effectively delivered potential treatment of spasticity in multiple sclerosis (MS) and for conditions like epilepsy, Harvest One Cannabis announced.
These findings were published in the journal Clinical Pharmacology in Drug Development, in the study “Single-Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology.”
The primary goal of the Phase 1 study (NCT03201835) was to evaluate the safety, pharmacokinetics (how a drug is absorbed, distributed and expelled) and tolerability of PTL101 capsules as a single administration of 10 or 100 mg of cannabidiol (CBD). Effects were compared to Sativex oromucosal spray — a therapy approved across Europe to treat MS-associated spasticity — that is also based on compounds from the cannabis plant, namely CBD and cannabinoids delta-9-tetrahydrocannabinol (THC). Sativex is produced by GW Pharmaceuticals.
A secondary objective was to compare the pharmacokinetic (how a drug is absorbed, distributed, metabolized and expelled) profile of THC, THC metabolite 11-hydroxy-THC and/or CBD following a single administration.
CBD is the main non-psychoactive component of the cannabis plant, and it has been associated with neuroprotective, anti-inflammatory, antiseizure, anxiolytic, antidepressant, and antipsychotic effects, Harvest One reported in a press release.
The trial was conducted by PhytoTech Therapeutics (PTL) in Israel using Satipharm’s proprietary GelpellR technology, a delivery system used to create PTL101 beads containing organically derived and pharmaceutical-grade CBD. Satipharm is a wholly owned Swiss subsidiary of Harvest One.
Results demonstrated the treatment’s safety and high performance, including the effective delivery of CBD. The trial also showed that PTL101 capsules had a favorable bioavailability (the fraction of an administered dose that circulates system-wide) when compared to Sativex.
A Phase 2 clinical trial (NCT02987114), also taking place in Israel, is now evaluating the efficacy of PTL101 capsules in treating pediatric refractory epilepsy. It is expected to conclude in December.
A possible Phase 2 clinical trial assessing PTL101’s safety and efficacy in treating spasticity-related symptoms in MS patients is in the planning stages.
Several studies have reported that cannabis-derived therapeutic products can be of benefit to patients with MS and other conditions.
One conducted by the National Academies of Sciences, Engineering, and Medicine and published in the National Academies Press highlighted that certain cannabinoids can reduce spasticity symptoms in MS patients. It is titled “The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research.”
This report, however, stressed that more research is needed to better understand the benefits and side effects of medical cannabis and cannabinoids.
The content on these pages are in no way intended to offer any related health benefits to our products but merely to share opinions and any research findings.
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